HCID 53465727, compound → 4-Phenyl-1-[[3-(trifluoromethyl)phenyl]methyl]-1H-1,2,3-triazole

Participants

Reaction Conditions

Reaction Steps

Route A: Pd(OAc)2 (0.449 g, 2.000 mmol) was added to a solution of 3 (0.858 g, 2 mmol) and TEA (0.281 ml, 2.000 mmol) in MeOH (10 ml). The sample was warmed to 55° C. for 4 h and monitored by LC-MS. Once the starting material had been consumed the sample was cooled and the volatile components were removed under vacuum. The crude residue was then purified by column chromatography (9:1 Hex:EtOAc-4:1 Hex:EtOAc) to give 4 (0.59 g, 1.945 mmol, 97% yield) as a white solid.

Provenance & Evidence