1-(Azidomethyl)-3-(trifluoromethyl)benzene → HCID 66958255, compound

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Reaction Steps

Synthesized from 2-fluoro-4-(3-iodoprop-2-ynyloxy)-6-(1-methyl-1H-pyrrol-2-yl)-1,3,5-triazine and 3-trifluoromethyl-benzylazide using general procedure; 0.311 g, 0.556 mmol, 80%; mp=185-187° C. (dec.); IR (υ[cm−1]) 3130, 3059, 1595, 1555, 1418, 1357, 1173, 1104, 1056, 911, 803, 756; 1H NMR (600 MHz, CDCl3) δ=7.61-7.58 (m, 2H), 7.50-7.41 (m, 3H), 6.90 (s, 1H), 6.21 (dd, J=3.9, 2.5, 1H), 5.64 (s, 2H), 5.56 (s, 2H), 4.09 (s, 3H); 13C NMR (151 MHz, CDCl3) δ=171.5 (dd, J=361.1, 15.4), 171.3, 169.8, 135.0, 133.0, 131.6 (q, J=32.8), 131.5, 129.9, 125.9 (q, J=3.6), 125.1 (q, J=3.7), 123.9 (q, J=272.4), 121.5, 81.6, 61.7, 54.0, 39.0; HRMS (ESI-TOF) (m/z): [M+H]+ calcd for C18H15F4IN7O, 560.0313; found 560.0311.

Provenance & Evidence