HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Butyn-2-ol, 4-iodo-2-methyl- → HCID 67776588, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Butyn-2-ol, 4-iodo-2-methyl- | HCID 11550243 | — |
| Reactant | 1-(Azidomethyl)-3-(trifluoromethyl)benzene | HCID 21282668 | — |
| Product | HCID 67776588 | HCID 67776588 | — |
Reaction Steps
Synthesized from 4-iodo-2-methylbut-3-yn-2-ol and 3-trifluoromethyl-benzylazide using general procedure; 3.82 g, 9.30 mmol, 93%; mp=77-80° C.; IR (υ[cm−1]) 3385, 2981, 2938, 1326, 1170, 1120, 1074, 763, 699; 1H NMR (600 MHz, CDCl3) δ=7.58-7.57 (m, 2H), 7.48-7.45 (m, 1H), 7.42-7.41 (m, 1H), 5.62 (s, 2H), 1.66 (s, 6H); 13C NMR (151 MHz, CDCl3) δ=156.4, 135.4, 131.5 (q, J=33.2), 131.4, 129.8, 125.7 (q, J=3.7), 125.1 (q, J=3.8), 123.9 (q, J=272.4), 74.2, 69.7, 53.8, 30.1; HRMS (ESI-TOF) (m/z): [M+H]+ calcd for C13H14F3IN3O, 412.0128; found 412.0126.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927736B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-dcdd10c7d6a44370bf05437a58c5b847 |
| Source note | uspto-grants-2015_01 |