p-Bromoacetophenone → 4'-Hydroxyacetophenone

Participants

Reaction Steps

Following general operating mode A, 4′-iodoacetophenone or 4′-bromo acetophenone (246 mg or 199 mg, 1.0 mmol) were reacted with cesium hydroxide at respectively 110 or 130° C. to afford the expected product in the form of a white solid at respective yields of 90% and 84% (eluant: ethyl acetate/heptane 20:80).

Provenance & Evidence