Cesium hydroxide → 4-Methoxyphenol

HRID 1424755Notes

Reaction equation

HRID 1424755 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6](I)=[CH:5][CH:4]=1.[OH-:10].[Cs+]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:10])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 62750Cesium hydroxideHCID 696764-Iodoanisole

Product 1

HCID 90154-MethoxyphenolYield 90%

Procedure

Following general operating mode A, 4-methoxyiodobenzene (246 mg, 1.0 mmol) is caused to react with cesium hydroxide to give the expected product in the form of a white solid with a yield of 90% (eluent: ethyl acetate/heptanes 20:80).

Sources & evidence

ORD record
ord-dbb80a737f3a43f8b0c0afc24382edeb
Source dataset
uspto-grants-2015_01
Patent number
US08927779B2

Reaction notes

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