Water → HCID 131732274, compound

Participants

Reaction Steps

Tf2O (0.157 mL, 0.930 mmol) in CH2Cl2 (1 mL) was added dropwise to a suspension of 2-(4-chlorophenyl)-5-cyclopropyl-6-(N-(3-fluoro-4-hydroxyphenyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide (328 mg, 0.620 mmol) and pyridine (0.251 mL, 3.10 mmol) in CH2Cl2 (5 mL) under N2 at room temperature. The mixture was stirred at room temperature for 3 h then water was added. The mixture was extracted with CH2Cl2 and the combined organic phases were dried over Na2SO4, filtered, concentrated at reduced pressure, and purified by flash chromatography on silica gel eluted (0-40% EtOAc/hexane) to give the desired compound as a white solid (410 mg, 83% yield). LCMS (m/z, ES+)=661 (M+H+).

Provenance & Evidence