Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1424836Generated: November 1, 2026

Benzoic acid, 5-[[5-cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-6-benzofuranyl](methylsulfonyl)amino]-2-nitro-, methyl ester → HCID 122643079, compound

https://huagongshe.com/reaction/1424836

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzoic acid, 5-[[5-cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-6-benzofuranyl](methylsulfonyl)amino]-2-nitro-, methyl esterHCID 122643071—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
ProductHCID 122643079HCID 12264307999.8%

Reaction Steps

A solution of methyl 5-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)-2-nitrobenzoate (1.33 g, 2.29 mmol) and 10% Pd/C (cat.) in MeOH (20 mL) was stirred under a hydrogen atmosphere (15 psi) for 1.5 h. The solution was filtered through celite and evaporated to afford the title compound (1.26 g, quant.) as a light yellow solid that was used without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08927593B2
Source datasetuspto-grants-2015_01
ORD IDord-2331ab5fa2ce4f3faed8e1a64d7c45ac
Source noteuspto-grants-2015_01