N-bromobutanimide → ethyl 4-bromo-5-ethyl-1H-imidazole-2-carboxylate

HRID 1424919Notes

Reaction equation

HRID 1424919 reaction equation
[CH2:1]([C:3]1[NH:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N:5][CH:4]=1)[CH3:2].C1C(=O)N([Br:20])C(=O)C1>>[Br:20][C:4]1[N:5]=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[NH:7][C:3]=1[CH2:1][CH3:2]

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 14990237Ethyl 5-ethyl-1H-imidazole-2-carboxylate2×

Product 1

HCID 67549138ethyl 4-bromo-5-ethyl-1H-imidazole-2-carboxylateYield 69%

Procedure

The same operation as in Example (1c) was performed using ethyl 5-ethyl-1H-imidazole-2-carboxylate obtained by the method described in Example (1b) (0.29 g, 1.30 mmol) and NBS (0.28 g, 1.28 mmol), to obtain 0.22 g of the title compound as a white solid (69%).

Workup

  1. customobtained by the method

Sources & evidence

ORD record
ord-21110e286a124f2b8b562db812f413ae
Source dataset
uspto-grants-2015_01
Patent number
US08927588B2

Reaction notes

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