tert-Butyl cis(+/-)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)benzoate → tert-Butyl cis(+/-)-3-(4-amino-3-methoxypiperidin-1-yl)benzoate
Reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:28]=[CH:29][CH:30]=2)[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:14][C@H:13]1[O:31][CH3:32])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:28]=[CH:29][CH:30]=2)[C:21]([O:23][C:24]([CH3:26])([CH3:27])[CH3:25])=[O:22])[CH2:14][C@H:13]1[O:31][CH3:32]Participants
3
Procedure
The same operation as in Example (40e) was performed using tert-butyl cis(±)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)benzoate obtained in Example (42c) (115 mg, 0.26 mmol) and a 10% palladium-carbon catalyst (40 mg), to obtain the title compound. The resulting compound was used for the next reaction without purification.
Sources & evidence
- ORD record
- ord-63e3fd18e0d949beba896afc69cec3f2
- Source dataset
- uspto-grants-2015_01
- Patent number
- US08927588B2
Reaction notes
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