1-Hydroxybenzotriazole → Ethyl cis(+/-)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-propoxypiperidin-1-yl)-4-(methylcarbamoyl)-1,3-thiazole-5-carboxylate

Participants

Reaction Steps

The same operation as in Example (1g) was performed using cis(±)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-propoxypiperidin-1-yl)-5-(ethoxycarbonyl)-1,3-thiazole-4-carboxylic acid obtained by the method described in Example (74c) (223 mg, 0.43 mmol), methylamine hydrochloride (60 mg, 0.89 mmol), WSC hydrochloride (260 mg, 1.36 mmol) and HOBT (60 mg, 0.44 mmol), to obtain 142.5 mg of the title compound as a white solid (77%).

Provenance & Evidence