Ethyl 5-ethyl-2-(4-nitrophenyl)-1,3-oxazole-4-carboxylate → HCID 67549117, compound

HRID 1425060Notes

Reaction equation

HRID 1425060 reaction equation
[CH2:1]([C:3]1[O:7][C:6]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=2)=[N:5][C:4]=1[C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH3:2]>[Pd].CO>[NH2:14][C:11]1[CH:10]=[CH:9][C:8]([C:6]2[O:7][C:3]([CH2:1][CH3:2])=[C:4]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[N:5]=2)=[CH:13][CH:12]=1

Participants

4

Reactant 1

HCID 68406117Ethyl 5-ethyl-2-(4-nitrophenyl)-1,3-oxazole-4-carboxylate

Product 1

HCID 67549117HCID 67549117, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The same operation as in Example (95b) was performed using ethyl 5-ethyl-2-(4-nitrophenyl)-1,3-oxazole-4-carboxylate obtained in Example (99a) (0.57 g, 2 mmol), 10% Pd/C (0.2 g) and methanol (10 mL), to obtain 0.45 g of the title compound as a yellow solid (88%).

Sources & evidence

ORD record
ord-bb30721583b8490699b624d4b562787e
Source dataset
uspto-grants-2015_01
Patent number
US08927588B2

Reaction notes

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