HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-(4-{[(benzyloxy)carbonyl]amino}-3-methylphenyl)-1,3-oxazole-4-carboxylate → Methyl 2-(4-amino-3-methylphenyl)-1,3-oxazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-(4-{[(benzyloxy)carbonyl]amino}-3-methylphenyl)-1,3-oxazole-4-carboxylate | HCID 68405856 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-(4-amino-3-methylphenyl)-1,3-oxazole-4-carboxylate | HCID 67548797 | 102.7% |
Reaction Steps
The same operation as in Example (95b) was performed using methyl 2-(4-{[(benzyloxy)carbonyl]amino}-3-methylphenyl)-1,3-oxazole-4-carboxylate obtained in Example (109d) (0.4 g, 1.09 mmol), 10% Pd/C (0.2 g) and methanol (10 mL), to obtain 0.26 g of the title compound as a colorless oily substance (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927588B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-b1ded0aaa91f4d0fb9de8accc19c7cba |
| Source note | uspto-grants-2015_01 |