HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → Tert-butyl cis(+/-)-4-amino-3-ethoxypiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | tert-Butyl cis(+/-)-4-(benzylamino)-3-ethoxypiperidine-1-carboxylate | HCID 86648597 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Tert-butyl cis(+/-)-4-amino-3-ethoxypiperidine-1-carboxylate | HCID 86648467 | 77.1% |
Reaction Steps
The same operation as in Example (90d) was performed using tert-butyl cis(±)-4-(benzylamino)-3-ethoxypiperidine-1-carboxylate obtained in Example (112c) (4.06 g, 12.1 mmol), 10% Pd/C (wet, 1.1 g), ammonium formate (2.87 g, 46 mmol) and methanol (30 mL), to obtain 2.28 g of the title compound as a colorless oily substance (94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927588B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-9f70b740c740451f9d5711e553b19d43 |
| Source note | uspto-grants-2015_01 |