Ammonium formate → Tert-butyl cis(+/-)-4-amino-3-propoxypiperidine-1-carboxylate

Participants

Reaction Steps

The same operation as in Example (90d) was performed using tert-butyl cis(±)-4-(benzylamino)-3-allyloxypiperidine-1-carboxylate obtained in Example (113c) (4.96 g, 14.3 mmol), 10% Pd/C (wet, 1.5 g), ammonium formate (5.42 g, 86 mmol) and methanol (30 mL), to obtain 3.41 g of the title compound as a colorless oily substance (93%).

Provenance & Evidence