HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86648633, compound → cis(+/-)-3-(2,2-Difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86648633 | HCID 86648633 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | cis(+/-)-3-(2,2-Difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-amine | HCID 86648634 | 95.3% |
Reaction Steps
The same operation as in Example (95b) was performed using cis(±)-N-benzyl-3-(2,2-difluoroethoxy)-1-(trifluoroacetyl)piperidin-4-amine obtained in Example (121d) (1.1 g, 3 mmol), 10% Pd/C (wet, 0.35 g) and methanol (10 mL), to obtain 0.79 g of the title compound as a colorless oily substance (95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927588B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-0ab56ea9c9584e1e904192542351a663 |
| Source note | uspto-grants-2015_01 |