Ammonium formate → tert-Butyl cis(+/-)-4-amino-3-(3-fluoropropoxy)piperidine-1-carboxylate

Participants

Reaction Steps

The same operation as in Example (95d) was performed using tert-butyl cis(±)-4-(benzylamino)-3-(3-fluoropropoxy)piperidine-1-carboxylate obtained in Example (127c) (1.06 g, 2.89 mmol), 10% Pd/C (wet, 0.4 g), ammonium formate (1.09 g, 17.4 mmol) and methanol (15 mL), to obtain 0.84 g of the title compound as a colorless oily substance (100%).

Provenance & Evidence