Methyl cis(+/-)-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate → Methyl cis(+/-)-4-(4-amino-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate
Reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([CH3:24])[N:21]=[C:20]([C:25]([O:27][CH3:28])=[O:26])[CH:19]=2)[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([CH3:24])[N:21]=[C:20]([C:25]([O:27][CH3:28])=[O:26])[CH:19]=2)[CH2:14][C@H:13]1[O:29][CH3:30]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The same operation as in Example (160c) was performed using methyl cis(±)-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate obtained in Example (168a) (190 mg) and a 10% palladium-carbon catalyst (200 mg), to obtain 129 mg of the title compound as a colorless oily substance. The resulting compound was used for the next reaction without purification.
Sources & evidence
- ORD record
- ord-a17ca590ecf04de5bd854414bbd910ae
- Source dataset
- uspto-grants-2015_01
- Patent number
- US08927588B2
Reaction notes
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