HCID 131730869, compound → Methyl cis(+/-)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methylbenzoate

HRID 1425244Notes

Reaction equation

HRID 1425244 reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[CH:20][C:21]([CH3:28])=[C:22]([CH:27]=2)[C:23]([O:25][CH3:26])=[O:24])[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[CH:20][C:21]([CH3:28])=[C:22]([CH:27]=2)[C:23]([O:25][CH3:26])=[O:24])[CH2:14][C@H:13]1[O:29][CH3:30]

Participants

3

Reactant 1

HCID 131730869HCID 131730869, compound

Product 1

HCID 86648723Methyl cis(+/-)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methylbenzoate

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

The same operation as in Example (160c) was performed using methyl cis(±)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methylbenzoate obtained in Example (172a) (39 mg, 0.09 mmol) and a 10% palladium-carbon catalyst (50 mg), to obtain the title compound. The resulting compound was used for the next reaction without purification.

Sources & evidence

ORD record
ord-c062f0ab2a8d4d8c82ca971cd30e3f26
Source dataset
uspto-grants-2015_01
Patent number
US08927588B2

Reaction notes

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