Diisopropylethylamine → Benzyl cis(+/-)-[3-methoxy-1-(6-methylpyrimidin-4-yl)piperidin-4-yl]carbamate

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	4-Chloro-6-methylpyrimidine	HCID 581796	—
Reactant	Benzyl cis(+/-)-[3-methoxypiperidin-4-yl]carbamate hydrochloride	HCID 86648698	—
Product	Benzyl cis(+/-)-[3-methoxy-1-(6-methylpyrimidin-4-yl)piperidin-4-yl]carbamate	HCID 86648724	—

Reaction Steps

The same operation as in Example (158a) was performed using benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride obtained in Example (160a) (549 mg, 1.83 mmol), 4-chloro-6-methylpyrimidine (235 mg, 1.83 mmol) and diisopropylethylamine (709 mg, 5.48 mmol), to obtain the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08927588B2
Source dataset	uspto-grants-2015_01
ORD ID	ord-49fc5b2175684e538ca4977b016cf1c0
Source note	uspto-grants-2015_01