HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → Ethyl 2-{3-[(tert-butoxycarbonyl)amino]azetidin-1-yl)-1,3-benzothiazole-7-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Aminoazetidine, 3-BOC protected | HCID 1519405 | — |
| Reactant | Ethyl 2-bromobenzo[d]thiazole-7-carboxylate | HCID 67073467 | — |
| Product | Ethyl 2-{3-[(tert-butoxycarbonyl)amino]azetidin-1-yl)-1,3-benzothiazole-7-carboxylate | HCID 67548709 | 92% |
Reaction Steps
The same operation as in Example (217a) was performed using 3-tert-butoxycarbonylaminoazetidine (300 mg, 1.74 mmol), ethyl 2-bromo-1,3-benzothiazole-7-carboxylate obtained in Example (1f) (332 mg, 1.16 mmol) and diisopropylethylamine (0.40 mL, 2.32 mmol), to obtain 403 mg of the title compound as a pale yellow solid (92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927588B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-8cfea3a50ca44d38a7a60d3f187044e5 |
| Source note | uspto-grants-2015_01 |