HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → Ethyl 2-{4-[(tert-butoxycarbonyl)(methyl)amino]piperidin-1-yl}-4-methyl-1,3-thiazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-N-Boc-4-N-Methyl-aminopiperidine | HCID 2756806 | — |
| Reactant | Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate | HCID 2824057 | — |
| Product | Ethyl 2-{4-[(tert-butoxycarbonyl)(methyl)amino]piperidin-1-yl}-4-methyl-1,3-thiazole-5-carboxylate | HCID 67549045 | 87.6% |
Reaction Steps
The same operation as in Example (217a) was performed using 4-[(tert-butoxycarbonyl)(methyl)amino]piperidine (386 mg, 1.80 mmol), ethyl 2-bromo-4-methylthiazole-5-carboxylate (300 mg, 1.20 mmol) and diisopropylethylamine (0.42 mL, 2.40 mmol), to obtain 403 mg of the title compound as a colorless oily substance (88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927588B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-bad54a58936249ce83c8d5bcc5a33d44 |
| Source note | uspto-grants-2015_01 |