HCID 59283052, compound → N-(7-hydroxy-9H-carbazol-2-yl)formamide

HRID 1425577Notes

Reaction equation

HRID 1425577 reaction equation
C([O:8][C:9]1[CH:21]=[C:20]2[C:12]([C:13]3[CH:14]=[CH:15][C:16]([NH:22][CH:23]=[O:24])=[CH:17][C:18]=3[NH:19]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:21]=[C:20]2[C:12]([C:13]3[CH:14]=[CH:15][C:16]([NH:22][CH:23]=[O:24])=[CH:17][C:18]=3[NH:19]2)=[CH:11][CH:10]=1

Participants

4

Reactant 1

HCID 59283052HCID 59283052, compound

Product 1

HCID 58160250N-(7-hydroxy-9H-carbazol-2-yl)formamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To N-(7-(benzyloxy)-9H-carbazol-2-yl)formamide (250 mg, 0.79 mmol) in 50 mL MeOH was added Palladium on activated carbon (60 mg). The mixture was stirred at rt under H2 atmosphere for 15 h. The mixture was concentrated under reduced pressure and dried under high vacuum to afford N-(7-hydroxy-9H-carbazol-2-yl)formamide mixed with the catalyst as a black solid (240 mg). This material was used directly for the next reaction without purification. MS (ESI) m/z 227 (M+H+).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-a3e7752f2db147c3a08ae213949f923c
Source dataset
uspto-grants-2015_01
Patent number
US08932557B2

Reaction notes

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