Dichloromethane → HCID 71059621, compound

Participants

Reaction Steps

[1,1′-Bis(diphenylphosphino)ferrocnee]dichloropalladium(II), w/DCM (7.32 mg, 8.96 μmol) was added to a solution containing 5-bromo-3-nitro-2-phenylpyridine (0.05 g, 0.179 mmol), (6-fluoropyridin-3-yl)boronic acid (0.025 g, 0.179 mmol), Copper(I) iodide (3.41 mg, 0.018 mmol) and Potassium carbonate (0.134 ml, 0.269 mmol) in DMF (Volume: 0.597 ml). Heated the reaction in a microwave at 110° C. for 15 minutes. Let the reaction cool to room temperature. Diluted reaction with water, dried, filtered, concentrated and purified with Combiflash using 0% to 25% ethyl acetate in hexanes to afford 6′-fluoro-5-nitro-6-phenyl-3,3′-bipyridine (0.03 g, 0.102 mmol, 56.7% yield).

Provenance & Evidence