HCID 71059611, compound → HCID 86674220, compound

HRID 1425599Notes

Reaction equation

HRID 1425599 reaction equation
C([O:8][C:9]1[CH:21]=[N:20][C:19]2[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[NH:12][C:11]=2[CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[N:20]1[C:19]2[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[NH:12][C:11]=2[CH:10]=[C:9]([OH:8])[CH:21]=1

Participants

4

Reactant 1

HCID 71059611HCID 71059611, compound

Product 1

HCID 86674220HCID 86674220, compoundYield 99.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3-(benzyloxy)-5H-pyrido[3,2-b]indole (0.09 g, 0.328 mmol) and Palladium 10% on carbon (0.035 g, 0.033 mmol) in MeOH (Volume: 5 ml) was stirred under hydrogen for 2 hours. Filtered and concentrated to afford 5H-pyrido[3,2-b]indol-3-ol (0.06 g, 0.326 mmol, 99% yield).

Workup

  1. filtrationFiltered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-bcad21fa92484fe6ba03e4fdb2f40598
Source dataset
uspto-grants-2015_01
Patent number
US08932557B2

Reaction notes

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