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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1425636Generated: October 31, 2026

Nap-226-90 → Rivastigmine

https://huagongshe.com/reaction/1425636

Reaction equation

Participants

RoleNameHCIDCharge
ReactantNap-226-90HCID 445892—
ReactantFormaldehyde formic acidHCID 18761834—
ProductRivastigmineHCID 77991—

Reaction Steps

Patent publication WO2006/068386 describes a process for preparation of 3-(1-dimethylamino)phenol by subjecting (S)-3-(1-dimethylaminoethyl)phenol to N-methylation using formaldehyde/formic acid. The 3-(1-dimethylamino)phenol it is subjected to O-carbamoylation to form rivastigmine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08932838B2
Source datasetuspto-grants-2015_01
ORD IDord-cab4c980f70941b19c4faab3b5c2f3f6
Source noteuspto-grants-2015_01