HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propargyl alcohol → N-Boc-beta-alanine Propargyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propargyl alcohol | HCID 7859 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | N-((1,1-dimethylethoxy)carbonyl)-beta-alanine | HCID 76809 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-Boc-beta-alanine Propargyl Ester | HCID 11831152 | — |
Reaction Steps
N-Boc-β-alanine (1.91 g, 10.1 mmol) and propargyl alcohol (0.675 g, 12 mmol) were dissolved in EtOAc (25 mL). Dicyclohexyl-carbodiimide (DCC, 2.06 g, 10 mmol) was added to the solution and after 16 h of stirring at room temperature, the reaction mixture was filtered and evaporated to dryness under vacuum. Crude product yield
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08932992B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-64cbcf2987294e898cf7aaf45ed3c614 |
| Source note | uspto-grants-2015_01 |