Beta-Alanine → N-Acetyl-beta-alanine

Participants

Reaction Steps

To a solution of β-alanine (2.25 g, 25 mmol) in aq. NaHCO3 (15 mL) was added acetonitrile (15 mL) and acetic anhydride (2.55 g, 25 mmol). The reaction mixture was stirred at room temperature for 3 h. Acetic anhydride (2.55 g. 25 mmol) was added and after 2 h and pH was adjusted to 4-5 by addition of NaH2PO4.

Provenance & Evidence