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Water → 4-Benzyloxy-1-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 4-Benzyloxy-2(1H)-pyridone | HCID 3607724 | — |
| 反応物 | 2-Bromo-1-(4-hydroxymethyl-2-methyl-phenyl)-ethanone | HCID 86695535 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 4-Benzyloxy-1-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one | HCID 86695537 | — |
反応手順
To a solution of 4-benzyloxy-1H-pyridin-2-one (728 mg, 3.62 mmol) in DMSO (4.00 mL) is added cesium carbonate (2.95 g, 9.05 mmol) and the mixture is stirred 15 min at room temperature. 2-Bromo-1-(4-hydroxymethyl-2-methyl-phenyl)-ethanone (preparation 1b, 880 mg, 3.62 mmol) is added in portions and the mixture and is stirred 2 h at room temperature. After addition of water, the precipitate is collected, washed with water and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08933079B2 |
| 出典データセット | uspto-grants-2015_01 |
| ORD ID | ord-5b707981018f4f728524e01a5f52f210 |
| 出典メモ | uspto-grants-2015_01 |