5-((5-fluoropyridin-2-yl)methoxy)pyridazin-3(2H)-one → 5-(5-Fluoro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	5-((5-fluoropyridin-2-yl)methoxy)pyridazin-3(2H)-one	HCID 58092258	—
Edukt	4-Benzyloxy-1-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one	HCID 86695537	—
Produkt	5-(5-Fluoro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one	HCID 86695547	91%

Reaktionsschritte

5-(5-Fluoro-pyridin-2-ylmethoxy)-2-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one is prepared following preparation 1c employing 5-(5-fluoro-pyridin-2-ylmethoxy)-2H-pyridazin-3-one (described in WO 09/103,478) instead of 4-benzyloxy-1H-pyridin-2-one.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08933079B2
Quelldatensatz	uspto-grants-2015_01
ORD ID	ord-94a3785fe0e844a4bcf6fffc72863f30
Quellennotiz	uspto-grants-2015_01