4-Benzyloxy-1-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one → 2-{2-[4-(1-Bromo-ethyl)-2-methyl-phenyl]-2-oxo-ethyl}-5-(5-methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one

HRID 1425759Notes

Reaction equation

HRID 1425759 reaction equation
C(OC1C=CN(CC(C2C=CC(C[Br:25])=CC=2C)=O)C(=O)C=1)C1C=CC=CC=1.O[CH:29]([C:31]1[CH:36]=[CH:35][C:34]([C:37](=[O:56])[CH2:38][N:39]2[C:44](=[O:45])[CH:43]=[C:42]([O:46][CH2:47][C:48]3[CH:53]=[CH:52][C:51]([O:54][CH3:55])=[CH:50][N:49]=3)[CH:41]=[N:40]2)=[C:33]([CH3:57])[CH:32]=1)[CH3:30].C(OC1C=CN(CC(C2C=CC(CO)=CC=2C)=O)C(=O)C=1)C1C=CC=CC=1>>[Br:25][CH:29]([C:31]1[CH:36]=[CH:35][C:34]([C:37](=[O:56])[CH2:38][N:39]2[C:44](=[O:45])[CH:43]=[C:42]([O:46][CH2:47][C:48]3[CH:53]=[CH:52][C:51]([O:54][CH3:55])=[CH:50][N:49]=3)[CH:41]=[N:40]2)=[C:33]([CH3:57])[CH:32]=1)[CH3:30]

Participants

4

Reactant 3

HCID 866955374-Benzyloxy-1-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-oneHCID 866955384-Benzyloxy-1-[2-(4-bromomethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-oneHCID 866955592-{2-[4-(1-Hydroxy-ethyl)-2-methyl-phenyl]-2-oxo-ethyl}-5-(5-methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one

Product 1

HCID 866955602-{2-[4-(1-Bromo-ethyl)-2-methyl-phenyl]-2-oxo-ethyl}-5-(5-methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-oneYield 93%

Procedure

2-{2-[4-(1-Bromo-ethyl)-2-methyl-phenyl]-2-oxo-ethyl}-5-(5-methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one is prepared following preparation 1d employing 2-{2-[4-(1-Hydroxy-ethyl)-2-methyl-phenyl]-2-oxo-ethyl}-5-(5-methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one instead of preparation 1c.

Sources & evidence

ORD record
ord-2c99886966644da58fba022b07e65530
Source dataset
uspto-grants-2015_01
Patent number
US08933079B2

Reaction notes

Loading…