HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Benzyloxy-1-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one → HCID 86695563, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Benzyloxy-1-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one | HCID 86695537 | — |
| Reactant | 4-Benzyloxy-1-[2-(4-bromomethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one | HCID 86695538 | — |
| Reactant | HCID 86695562 | HCID 86695562 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | HCID 86695563 | HCID 86695563 | 80% |
Reaction Steps
1-[2-(4-Bromomethyl-2-methyl-phenyl)-2-oxo-ethyl]-4-(5-methoxy-pyridin-2-ylmethoxy)-1H-pyridin-2-one is prepared following preparation 1d employing 1-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-4-(5-methoxy-pyridin-2-ylmethoxy)-1H-pyridin-2-one (preparation 11c) instead of preparation 1c. The reaction mixture is stirred overnight. Tert-butyl methyl ether is added and the resulting precipitate is filtered off and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08933079B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-ddb0b1f41830460493a66c70805bc09a |
| Source note | uspto-grants-2015_01 |