Piperidin-4-ol → HCID 86695569, compound

Participants

Reaction Steps

To a mixture of 1-[2-(4-bromomethyl-2-methyl-phenyl)-2-oxo-ethyl]-4-(5-methoxy-pyridin-2-ylmethoxy)-1H-pyridin-2-one (preparation 11d, 129 mg, 0.28 mmol) in CH2Cl2 (2 mL) is added 4-hydroxypiperidine (85 mg, 0.84 mmol). The reaction mixture is stirred overnight at room temperature. The mixture is purified via reverse phase HPLC chromatography (Waters Xbridge C18 5 μm, gradient 50%→95% methanol in water+0.1% NH4OH, 120 mL/min).

Provenance & Evidence