反应详情

温度

80 °C

To a solution of 2-(4-methoxyphenyl)acetic acid (10 g, 0.06 mol) in PPA (20 mL) was added dropwise phenol (5.6 g, 0.06 mol) under an inert atmosphere. The mixture was then stirred at 80° C. for 1 h, quenched with cold water and extracted with EtOAc (2×300 mL). The combined organic layers were dried over Na2SO4 and concentrated in vacuo to obtain the crude product which was purified via silica gel column chromatography to afford 1-(4-hydroxyphenyl)-2-(4-methoxyphenyl)-ethanone (3 g, 20%) as a pale yellow solid

1. customquenched with cold water
2. extractionextracted with EtOAc (2×300 mL)
3. dry with materialThe combined organic layers were dried over Na2SO4
4. concentrationconcentrated in vacuo
5. customto obtain the crude product which
6. customwas purified via silica gel column chromatography