Hydrochloric Acid → HCID 86702794, compound

Participants

Reaction Steps

To a solution of tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{bis[(tert-butoxy)carbonyl]amino}pentanoate XXII (3.00 g, 4.04 mmol) in EtOAc (20 mL) was added HCl (3.5 M solution in EtOAc, 20 mL). The reaction mixture was stirred for 30 min at room temperature before adding ethyl ether (about 50 mL). The precipitate was filtered and washed with ether to give tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-aminopentanoic acid as a white crystalline solid (1.82 g, 3.14 mmol, 78% yield).

Provenance & Evidence