Potassium Hydroxide → HCID 59367308, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (˜10° C.) solution of KOH (13.2 g, 235 mmol) in MeOH (50 mL) was added the solution of 2-isocyanoacetamide (LXXIV) in MeOH (60 mL) dropwise while maintaining the temperature at 10-15° C. A solution of 4-(trifluoromethyl)benzaldehyde (40.9 g, 235 mmol) in MeOH (50 mL) was then added and the reaction was stirred for an additional 2 h. The reaction mixture was cooled to −20° C. causing a white solid to precipitate. The solid was filtered and dried to give crude (5R)-5-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole-4-carboxamide (LXXV) (62 g). The crude product was used for the next step without purification.

Provenance & Evidence