HCID 68281404, compound → HCID 57385799, compound

Participants

Reaction Steps

(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-phenylene)dimethanol (CVII) (2.0 g, 7.57 mmol) was dissolved in 6 M aqueous HCl (100 ml) at 60° C. and stirred overnight. The reaction mixture was concentrated under vacuum and the oily residue was triturated with Et2O to give a light-brown solid. The solid was removed by filtration and washed with Et2O. The filtrate (which according to LC/MS contained the product) was concentrated under vacuum to give 6-(hydroxymethyl)benzo[c][1,2]oxaborol-1(3H)-ol (CVIII) (0.63 g, 3.84 mmol, 35% purity). ESIMS found for C8H9BO3 m/z 163.0 (M−H). The crude product was used without further purification for Step 5.

Provenance & Evidence