HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-hydroxypyridine → 4-bromo-1-[(R)-tetrahydro-furan-3-yl]-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| Reactant | (S)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate | HCID 13837326 | — |
| Product | 4-bromo-1-[(R)-tetrahydro-furan-3-yl]-1H-pyridin-2-one | HCID 58564190 | 18% |
Reaction Steps
The title compound was prepared from 4-bromo-1H-pyridin-2-one and (S)-toluene-4-sulfonic acid tetrahydrofuran-3-yl ester following a procedure analogous to that described for Intermediate 8. Yield: 18% of theory; LC (method 3): tR=2.18 min; Mass spectrum (ESI+): m/z=244/246 (Br) [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08933072B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-f0e89774ced3477dafca2fa9e0fbfefb |
| Source note | uspto-grants-2015_01 |