HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 1-(6-Bromo-pyridin-2-yl)-cyclopropanecarboxylic acid methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 1-(6-Bromopyridin-2-YL)cyclopropane-1-carboxylic acid | HCID 72211995 | — |
| Product | 1-(6-Bromo-pyridin-2-yl)-cyclopropanecarboxylic acid methylamide | HCID 86696135 | 70% |
Reaction Steps
The title compound was prepared from 1-(6-bromo-pyridin-2-yl)-cyclopropanecarboxylic acid and methylamine (2 mol/L in tetrahydrofuran) following a procedure analogous to that described in Step 2 for Intermediate 5. Yield: 70% of theory; LC (method 3): tR=2.27 min; Mass spectrum (ESI+): m/z=255/257 (Br) [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08933072B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-6808309e2e1b487592bec2f7e380d903 |
| Source note | uspto-grants-2015_01 |