5-Bromo-2-chloropyrimidine → HCID 67997452, compound

HRID 1425987Notes

Reaction equation

HRID 1425987 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5](Cl)=[N:6][CH:7]=1.Cl.[F:10][C:11]1([F:15])[CH2:14][NH:13][CH2:12]1>>[Br:1][C:2]1[CH:3]=[N:4][C:5]([N:13]2[CH2:14][C:11]([F:15])([F:10])[CH2:12]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 6066655-Bromo-2-chloropyrimidineHCID 27582473,3-Difluoroazetidine hydrochloride

Product 1

HCID 67997452HCID 67997452, compound

Procedure

The title compound was prepared following a procedure analogous to that described for Intermediate 27 using 5-bromo-2-chloropyrimidine and 3,3-difluoroazetidine hydrogen chloride salt. LC (method 5): tR=1.57 min; Mass spectrum (ESI+): m/z=250/252 (Br) [M+H]+.

Sources & evidence

ORD record
ord-772c0ad1c97241db8030601775efadae
Source dataset
uspto-grants-2015_01
Patent number
US08933072B2

Reaction notes

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