HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-fluoropyridine → HCID 67997620, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-fluoropyridine | HCID 2783168 | — |
| Reactant | (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one | HCID 59532385 | — |
| Product | HCID 67997620 | HCID 67997620 | 71% |
Reaction Steps
The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-{(S)-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-ethyl}-1,3-oxazinan-2-one and 5-bromo-2-fluoro-pyridine following a procedure analogous to that described in Example 1. Yield: 71% of theory; Mass spectrum (ESI+): m/z=449 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08933072B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-f2313b4f95514c83af86b6866240aeed |
| Source note | uspto-grants-2015_01 |