Hydrochloric Acid → 1-[6-(4-{(S)-1-[(S)-6-(2-hydroxy-2-methyl-propyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}-phenyl)-pyridazin-3-yl]-cyclopropanecarboxylic acid

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Reaction Steps

4 M aqueous NaOH solution (1.5 mL) was added to a solution of 1-[6-(4-{1-[6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]-ethyl}-phenyl)-pyridazin-3-yl]-cyclopropane-carboxylic acid ethyl ester (0.81 g) in methanol (5 mL) at room temperature. The solution was stirred at room temperature for 2 h and was then neutralized with 1 M aqueous hydrochloric acid. Most of the methanol was evaporated, the residue was diluted with water, and the resulting mixture was extracted with ethyl acetate. The combined extracts were washed with brine, dried (Na2SO4), and concentrated to give the title compound as a solid. Yield: 0.72 g (93% of theory); LC (method 1): tR=1.44 min; Mass spectrum (ESI+): m/z=516 [M+H]+.

Provenance & Evidence