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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1426014Generated: October 31, 2026

Ammonia → HCID 54771078, compound

https://huagongshe.com/reaction/1426014

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmoniaHCID 222—
Reactant1-[6-(4-{(S)-1-[(S)-6-(2-hydroxy-2-methyl-propyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}-phenyl)-pyridazin-3-yl]-cyclopropanecarboxylic acidHCID 67998423—
ProductHCID 54771078HCID 5477107850%

Reaction Steps

The title compound was prepared from 1-[6-(4-{(S)-1-[(S)-6-(2-hydroxy-2-methyl-propyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}-phenyl)-pyridazin-3-yl]-cyclopropanecarboxylic acid and ammonia (32% in water) following a procedure analogous to that described in Step 2 for Intermediate 5. Yield: 50% of theory; LC (method 1): tR=1.72 min; Mass spectrum (ESI+): m/z=515 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08933072B2
Source datasetuspto-grants-2015_01
ORD IDord-49e9e3776622496c8113b01db85b0230
Source noteuspto-grants-2015_01