4-bromo-1-[(R)-tetrahydro-furan-3-yl]-1H-pyridin-2-one → (S)-6-(2-Hydroxy-2-methyl-propyl)-3-((S)-1-{4-[2-oxo-1-((R)-tetrahydro-furan-3-yl)-1,2-dihydro-pyridin-4-yl]-phenyl}-ethyl)-6-phenyl-[1,3]oxazinan-2-one

Participants

Reaction Steps

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-{(S)-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-ethyl}-1,3-oxazinan-2-one and 4-bromo-1-[(R)-tetrahydro-furan-3-yl]-1H-pyridin-2-one following a procedure analogous to that described in Example 1. Yield: 65% of theory; LC (method 3): tR=2.95 min; Mass spectrum (ESI+): m/z=517 [M+H]+.

Provenance & Evidence