HCID 45787747, compound → HCID 54771313, compound

Participants

Reaction Steps

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-{(S)-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl}-1,3-oxazinan-2-one and 1-(5-bromothiazol-2-yl)pyridin-2(1H)-one following a procedure analogous to that described in Example 31. LC (method 5): tR=1.72 min; Mass spectrum (ESI+): m/z=472, 530 [M+H]+; 1H NMR (CDCl3) δ 1.12 (s, 3H), 1.18 (s, 3H), 1.56 (d, 3H), 2.19 (s, 2H), 2.25 (m, 1H), 2.39 (m, 1H), 2.60 (m, 1H), 2.86 (m, 1H), 5.69 (q, 1H), 6.45 (t, 1H), 6.80 (d, 1H), 6.99 (d, 2H), 7.25-7.40 (7H), 7.46 (m, 1H), 7.77 (s, 1H), 8.81 (d, 1H).

Provenance & Evidence