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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1426049Generated: October 29, 2026

Ammonia → HCID 70651835, compound

https://huagongshe.com/reaction/1426049

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmoniaHCID 222—
Reactant1-[4-(4-{(S)-1-[(S)-6-(2-hydroxy-2-methyl-propyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acidHCID 67997885—
ProductHCID 70651835HCID 7065183568%

Reaction Steps

The title compound was prepared from 1-[4-(4-{(S)-1-[(S)-6-(2-hydroxy-2-methyl-propyl)-2-oxo-6-phenyl-[1,3]oxazinan-3-yl]ethyl}-phenyl)-pyridin-2-yl]-cyclopropanecarboxylic acid and ammonia (32% in water) following a procedure analogous to that described in Step 2 for Intermediate 5. Yield: 68% of theory; LC (method 1): tR=2.45 min; Mass spectrum (ESI+): m/z=514 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08933072B2
Source datasetuspto-grants-2015_01
ORD IDord-9e76ecab873f46c9abb2d61597dc285d
Source noteuspto-grants-2015_01