Prolinamide, D- → HCID 70652126, compound

HRID 1426058Notes

Reaction equation

HRID 1426058 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C@@H:14]([N:16]3[CH2:21][CH2:20][C@:19]([CH2:28][C:29]([OH:32])([CH3:31])[CH3:30])([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[O:18][C:17]3=[O:33])[CH3:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[NH:34]1[CH2:41][CH2:40][CH2:39][C@@H:35]1[C:36]([NH2:38])=[O:37]>>[OH:32][C:29]([CH3:31])([CH3:30])[CH2:28][C@@:19]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[O:18][C:17](=[O:33])[N:16]([C@H:14]([C:11]2[CH:12]=[CH:13][C:8]([C:5]3[N:6]=[N:7][C:2]([N:34]4[CH2:41][CH2:40][CH2:39][C@@H:35]4[C:36]([NH2:38])=[O:37])=[CH:3][CH:4]=3)=[CH:9][CH:10]=2)[CH3:15])[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 447554Prolinamide, D-HCID 86696138HCID 86696138, compound

Product 1

HCID 70652126HCID 70652126, compoundYield 26%

Procedure

The title compound was prepared from 3-{(S)-1-[4-(6-chloro-pyridazin-3-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one and D-prolinamide following a procedure analogous to that described in Example 53. Yield: 26% of theory; Mass spectrum (ESI+): m/z=544 [M+H]+.

Sources & evidence

ORD record
ord-c9b890dd5d3442498b8ab8ee2af009a4
Source dataset
uspto-grants-2015_01
Patent number
US08933072B2

Reaction notes

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