Potassium Carbonate → HCID 86639657, compound

Participants

Reaction Steps

5-Bromo-2-(4-methylthiazol-2-ylamino)pyridin-3-ol (prepared according to Example 3, Step A; 0.100 g, 0.349 mmol), K2CO3 (0.109 g, 0.786 mmol), and 1-(chloromethyl)-3-methoxybenzene (0.070 g, 0.349 mmol) were reacted according to Example 3, Step B, to provide 3-(3-methoxybenzyloxy)-5-bromo-N-(4-methylthiazol-2-yl)pyridin-2-amine hydrochloride (0.010 g, 7.04% yield). 1H NMR (d6-DMSO) δ 7.98 (m, 1H), 7.65 (s, 1H), 7.32 (t, 1H), 7.18 (s, 1H), 7.13 (d, 1H), 6.92 (dd, 1H), 6.66 (s, 1H), 5.27 (s, 2H), 3.77 (s, 3H), 2.25 (s, 3H). Mass spectrum (apci) m/z=406.0 (M+H-HCl).

Provenance & Evidence