m-Chloroperbenzoic acid → 3-(benzyloxy)-N-(4-methylthiazol-2-yl)-5-(phenylsulfinyl)pyridin-2-amine hydrochloride

Participants

Reaction Steps

3-(Benzyloxy)-N-(4-methylthiazol-2-yl)-5-(phenylthio)pyridin-2-amine (0.049 g, 0.121 mmol) (prepared according to Example 7; 0.049 g, 0.121 mmol) and MCPBA (0.0398 g, 0.166 mmol) were reacted according to Example 8 to provide 3-(benzyloxy)-N-(4-methylthiazol-2-yl)-5-(phenylsulfinyl)pyridin-2-amine hydrochloride (0.028 g, 50.6% yield). 1H NMR (DMSO-d6) δ 8.25 (d, 1H), 7.70 (m, 2H), 7.59 (s, 1H), 7.56 (m, 5H), 7.34 (m, 3H), 6.79 (s, 1H), 5.31 (s, 2H), 2.28 (s, 3H). Mass spectrum (apci) m/z=422.0 (M+H-HCl).

Provenance & Evidence