Hydrochloric Acid → HCID 86639679, compound

Participants

Reaction Steps

Methyl 3-(5-(benzyloxy)-6-(4-methylthiazol-2-ylamino)pyridin-3-ylthio)propanoate (prepared according to Example 42; 70 mg, 0.17 mmol), KOtBu (0.59 mL, 0.59 mmol) and 1-(chloromethyl)-4-methoxybenzene (0.023 mL, 0.17 mmol) were reacted according to the method of Example 43 to afford 5-(4-methoxybenzylthio)-3-(benzyloxy)-N-(4-methylthiazol-2-yl)pyridin-2-amine hydrochloride (64.1 mg, 78.3% yield) as a white solid after HCl salt formation. 1H NMR (d6-DMSO) δ 7.82 (d, 1H), 7.60-7.54 (m, 3H), 7.45-7.34 (m, 3H), 7.13 (m, 2H), 6.82 (m, 3H), 5.30 (s, 2H), 4.14 (s, 2H), 3.70 (s, 3H), 2.30 (d, 3H); Mass spectrum (apci) m/z=450.0 (M+H-HCl).

Provenance & Evidence