Hydrochloric Acid → HCID 86639689, compound

Participants

Reaction Steps

(E)-3-(benzyloxy)-5-(3-(dimethylamino)prop-1-enyl)-N-(4-methylthiazol-2-yl)pyridin-2-amine (140 mg, 0.368 mmol) and 4-methylbenzenesulfonohydrazide (343 mg, 1.84 mmol) were reacted according to the method of Example 93 to afford the title compound (52 mg, 31.0% yield) as a white solid after HCl salt formation. 1H NMR (DMSO-d6) δ 11.05 (bs, 1H), 10.66 (bs, 1H), 7.87 (s, 1H), 7.62 (m, 3H), 7.45-7.32 (m, 3H), 6.83 (s, 1H), 5.34 (s, 2H), 2.98 (m, 2H), 2.71 (d, 6H), 2.66 (t, 2H), 2.31 (s, 3H), 2.01 (m, 2H). Mass spectrum (apci) m/z=383.2 (M+H-2HCl).

Provenance & Evidence